Product Name Prescription Required? Parasites Safe For Other Pets Side Effects Water Resistance Special Concerns Minimum Age/Size Active Ingredient
Sentry Natural Defense no fleas and ticks yes skin irritation, hair loss, yes; but can be removed with soap shortly after applications very heavy clove scent; may have shorter duration than some other products 12 weeks octopamine blocker
Frontline Plus no fleas, ticks, lice provided for cats as well, indicated safe for nursing and pregnant dogs   yes   8 weeks fipronil and s-methoprene
Advantage Multi yes flea, heartworms, whipworms, roundworms, hookworms also available for cats, no information on prenant or nursing dogs skin irritation, lethargy, loss of appetite, hyperactivity   medicinal odor, serious concerns if ingested including incoordination and tremors 7 weeks and 3 lbs imidacloprid, moxidectin
Bio Spot no fleas, ticks and mosquitos lethal to cats and other animals excessive salivation, seizures, muscle tremors, twitching, dilated pupils bathing can dilute effectiveness, water resistant not for use in young puppies, not to be combined with any other products 6 months permethrin, s-methoprene IGR
Sentinel yes fleas, heartworms, roundworms, hookworms, whipworms safe for use in cats, pregnant and nursing dogs depression, lethargy, vomiting, staggering, loss of appetite, diarrhea, seizures, weakness, excessive salivation   does not kill adult fleas, often used in combination with Capstar; beef flavor; must give with food; special caution for use in Collies and other herding breeds 4 weeks and 2 lbs milbemycin oxime, lufenuron
K9 Advantix no fleas, ticks, mosquitos no   yes   7 weeks   imidacloprid, permethrin
Revolution yes fleas, ticks, heartworms, ear mites, sarcoptic mange yes, sold for cats as well, safe for pregnant and nursing dogs loss of appetite, salivation, diarrhea, vomiting, tremors, fever, panting, skin irritation yes (within 2 hours of application) one spot application 6 weeks selamectin
Capstar no fleas yes, sold for cats as well, safe for pregnant and nursing dogs   yes not a preventative, safely dose as often as once a day; fast acting 4 weeks nitepyram